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Echelon提供各种抗体、分析检测试剂盒和抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。
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echelon-inc/Anti-PEth Autologous IgG ELISA/1kit/K-5000A-1kit

echelon-inc/Anti-PEth Autologous IgG ELISA/1kit/K-5000A-1kit
  • echelon-inc/Anti-PEth Autologous IgG ELISA/1kit/K-5000A-1kit
商品介绍

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CatalogNo.: K-5000A

Description: EchelonBioscience’sHumanAnti-PEthAutologousIgGELISAisadirectassayinwhichthesignalisproportionaltotheamountofautologousanti-PEthIgGcontainedinthesample.Theserum(orplasma)sampleisaddedtoaPEth-coatedplateforbinding.Aperoxidase-linkedsecondarydetectorandcolorimetricsubstrateareusedtodetecttheamountofanti-PEthantibodyboundtotheplate.Thecolorimetricsignalisreadatabsorbance450nmandisdirectlyproportionaltotheamountofautologousanti-PEthIgGinthesample.

Ethanol(EtOH)hasmultipleeffectsonhumansandotheranimals.Alcoholaddictionandorgandamageareactiveareasofresearchwithaneedforresearchreagentsandtools.1Phosphatidylethanol(PEth)isadirectmetaboliteofEtOHandhasbeendescribedasalong-livedbioMarkerforalcoholingestion.2,3ItispossIBLethatPEthisinvolvedintheneurological4,protective5,andharmful6effectsofalcohol,butthemechanismsarestillbeingexplored.
Autologousanti-PEthantibodiesarefoundinlowerabundanceinserumfromheavierdrinkers.Thisinverserelationshipbetweenanti-PEthIgGlevelsandalcoholingestionwasfirstreported,byNissinenet.al.7EvaluationofserumsamplesofvaryingconsumptionhABItshasdemonstratedahighdegreeofcorrelationwithingestedalcohol.Measuringtheseautologousanti-PEthIgGlevelsmayserveasaneffectivebiomarkerinmonitoringalcoholuse.

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4°C

References

1.Freeman,W.M.;Vrana,K.E.FutureProspectsforbiomarkersofalcoholconsumptionandalcohol-induceddisorders.AlcoholClinExpRes2010,34,946-54.
2.Viel,G.;etal.Phosphatidylethanolinbloodasamarkerofchronicalcoholuse:asystematicreviewandmeta-analysis.IntJMolSci2012,13,14788-812.
3.Wurst,F.M.;etal.Phosphatidylethanol:normalizationduringdetoxification,genderaspectsandcorrelationwithotherbiomarkersandself-reports.AddictBiol2010,15,88-95.
4.Esteban-Pretel,G.;etal.PolyphosphoinositidemetabolismandGolgicomplexmorphologyinhippocampalneuronsinprimarycultureisalteredbychronicethanolexposure.AlcoholAlcohol2012,48,15-27.
5.Foster,D.A.;etal.Reducedmortalityandmoderatealcoholconsumption:thephospholipaseD-mTORconnection.CellCycle2010,9,1291-4.
6.Pannequin,J.;atal.PhosphatidylethanolaccumulationpromotesintestinalhyperplasiabyinducingZONAB-mediatedcelldensityincreaseinresponsetochronicethanolexposure.MolCancerRes2007,5,1147-57.
7.Nissinen,A.E.;etal.Lowplasmaantibodiesspecificforphosphatidylethanolinalcoholabusersandpatientswithalcoholicpancreatitis.AddictBiol,2011.17(6):p.1057-67.

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品牌介绍

Echelon Biosciences Incorporated (EBI) was incorporated under the laws of the state of Utah as Echelon Research Laboratories, Inc. on October 3, 1997. Initially, EBI was formed from a project under the Center for Cell Signaling, a State of Utah Center of Excellence, with the aim to further the science of lipid cell signaling and critical metabolic enzymes, which provide new and viable targets for the development of potential drugs and diagnostics for cancer, diabetes, inflammation, infections, and cardiovascular disease.

From 1997 through 2004, EBI primarily used government grants and product sales revenues to fund its research efforts. In early 2005, EBI was purchased by Aeterna Zentaris (NAS: AEZS) for its MEP anti-infectives, PI3-Kinase small molecule program, catalog business, and scientific expertise. In late 2007, Frontier Scientific Incorporated (FSI) based in Logan, Utah purchased EBI. Specializing in porphyrin and boron chemistry, FSI opened the doors for expanded research.

Since 1997, EBI has retained its commitment to developing novel assays and reagents for lipid research and beyond. At EBI’s core is the desire to innovate, thus pushing medicinal research to new limits. We look forward to providing scientists around the world with the tools they need to cure human disease states for years to come and we welcome any suggestions about how we can better do so.



苏州蚂蚁淘生物科技有限公司是一家创新型高科技生物公司,以常规生物学实验外包与生物学试剂为基础,放眼于生命科学领域的前沿技术服务,公司技术骨干有着多年的生物学科研背景,毕业于国内外名牌大学,并且有着丰富的项目经验,了解国内外科研行情,我公司力求为每一个客户提专业、针对性的实验方案。我公司以技术服务为支点,和国内外多家生物试剂公司有着密切的业务往来.公司特色技术服务包括:抗体药物研发、噬菌体抗体库、蛋白表达与传化、抗体制备、高通量测序、组学研究、生物信息学分析与方法建立、基础分子生物学技术外包、化学中间体合成、原料药物研发、论文编写等。我公司秉承”诚信做人,认真做事,服务至上“,希望用我们的专业知识和项目经验为国内科研客户解决科研问题,祝您科研之路畅通无阻!


      Echelon 于1997 年在美国犹他州成立,其前身是美国国家级细胞信号研究中心。Echelon 提供各种抗体、分析检测试剂盒、抑制剂等产品,尤其擅长以细胞信号、脂类代谢和标记物研究为主的相关产品。为研究治疗诸如癌症、糖尿病、炎症、感染和心脑血管疾病专家提供全面有效工具。

      苏州蚂蚁淘生物科技有限公司是Echelon的中国代理商,负责Echelon产品在中国的销售。


      一笔230万美元的国防部赠款将帮助神经科学家为急诊室和战场开发新的治疗方法。这项研究将集中于开发新的疗法,以帮助保护大脑和其他在创伤、心脏病发作或中风后处于危险中的器官。

      罗彻斯特大学医学中心的神经学家Marc Halterman, M.D., Ph.D该研究的首席研究员说:“虽然我们在中风或心脏骤停后恢复血液流动的能力方面取得了重大进展,但医学界并没有药物来防止这些事件发生后的继发性损害。“这项资助将进一步推进我们对一类既具有抗炎作用又具有细胞保护作用的药物的研究,我们相信这类药物将适用于军事和紧急情况。”

      该项目是与盐湖城的一个合成抗生素化学家团队合作开发的,该团队由Mark Nelson, Ph.D领导,他将担任Echelon Biosciences的副研究员。

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